When is a multi-region caching strategy worth the complexity for read-heavy apps?

Okay, so you're building a new app, right, and it's going to be read-heavy with users all over the world. You're trying to figure out if you should go with multi-region caching, like a CDN for static stuff and something like Redis Enterprise for dynamic data. Or maybe just stick to a single-region cache and focus on making that work well for different regions. Going multi-region looks like it would make things a lot faster for people who aren't near your main data center. But man, that also means a lot more work for operations, especially with keeping data up-to-date and consistent. So, in your experience, when does multi-region caching actually become worth all that extra hassle for an app that's mostly reads? Are there particular ways people use the app, or certain kinds of data, that just make it a must-have?