when to ditch a caching layer

Hey everyone, we've been thinking about our caching strategy, and I'm curious about other perspectives. We're using Redis a lot for caching API responses and some database queries, which really helps speed things up. But, as our infrastructure gets bigger, so does the hassle of managing cache invalidation and the Redis cluster itself. Are there times when dealing with a cache is more trouble than it's worth? Have any of you ever gotten rid of a caching layer, or maybe just simplified it a lot, and why did you do it?