user-generated content cdn best practices

hey folks, im setting up a new platform where users upload images and videos. were planning to use a CDN to serve this content globally. beyond basic caching, what are your go-to strategies for optimizing performance and cost for user-generated content on a CDN? thinking about things like image optimization on the fly, regional balancing, or specific configurations for different file types. anyone have war stories or success with particular CDN providers for this use case?